摘要
目的测定胃液中的胆红素浓度以评价二甲基硅油对胆汁反流的疗效．方法慢性胃炎患者６５例，其中伴胆汁反流４５例，进一步分成２组：治疗组（３０例）在测定前服二甲基硅油＋硫糖铝；对照组（１５例）单服硫糖铝．用胆红素氧化酶法测定胆红素浓度．结果无胆汁反流的２０名患者中，胃液中胆红素浓度分别检测１５例为０，５例为０４μｍｏｌ／Ｌ～０８μｍｏｌ／Ｌ；治疗组在服二甲基硅油前后均值分别为（１６０±１２０）μｍｏｌ／Ｌ和（６６±４９）μｍｏｌ／Ｌ（Ｐ＜００１），而对照组则分别为（１４６±１２３）μｍｏｌ／Ｌ和（１５９±１９８）μｍｏｌ／Ｌ（Ｐ＞００５）；胆红素浓度减少３０％以上者治疗组中占８００％，对照组中占２６７％，两组间有高度显著差异（χ２＝１２１００８．Ｐ＜００１）．结论测定胃液中胆红素有助于判断胆汁反流，并肯定二甲基硅油可减少胆汁反流，从而减轻胆汁反流性胃炎．
AIM The bilirubin level in gastric juice was determined to judge the therapeutic effect of dimethicone on bile reflux. METHODS Sixty five patients with chronic gastritis were studied. Among them 45 had bile reflux and 20 had not. The former were further divided into 2 groups: treatment group ( n =30) taking dimethicone plus ulcerlmin before the determination of gastric juice bilirubin by the method of bilirubin oxidase and control group ( n =15) only taking ulcerlmin.
关键词
二甲基喹油
胃炎
胆汁反流
胆红素
Dimethicone/pharmcology Bile reflux/drug therapy Bilirubin/metabolism
