咽旁间隙肌上皮癌的影像学及临床病理分析

Image date and clinicopathologic features of myoepithelial carcinoma in parapharyngeal space

目的:探讨咽旁间隙肌上皮癌的影像学及临床病理特征。方法:分析我院收治的1例咽旁间隙肌上皮癌患者的影像学及临床病理资料,结合文献探讨头颈部肌上皮癌的临床特征。结果:影像学显示咽旁间隙占位性病变;病理学确诊为肌上皮癌,病理免疫组织化学表现为S-100蛋白、平滑肌动蛋白、细胞角蛋白、波形蛋白免疫组织化学阳性染色。临床表现为耳痛、流脓血伴头痛及脑神经损害。结论:肌上皮癌是罕见的预后极差的恶性上皮性肿瘤,好发于颌面部涎腺;发生于咽旁间隙并侵犯颞骨则表现为耳深部疼痛及头痛。影像学表现恶性肿瘤行为,破坏性强。病理免疫组织化学明确诊断。

Objective：To study the image data and clinicopathologic features of myoepithelial carcinoma in parapharyngeal space. Method：Based on one patient with myoepithelial carcinoma of parapharyngeal space treated in our hospital, image data and clinicopathologic findings were analyzed. The clinical characteristics of myoepithelial carcinoma in head and neck region were discussed. Result..CT obviously showed the mass in parapharyngeal space with destruction of temporal bone. Immunohistochemicalstain showed positive staining for S-100 protein, Smooth muscle actin, Cytokeratin and Vimentin. There were otalgia, bloody pus, headache and signs of cranial nerve lesion. Conclusion.. Myoepithelial carcinoma was a rare malignant epithelial neoplasm and had a poor prognosis. Myoepithelial carcinoma often occurrenced in salivary gland of maxillofacial region. The clinical signs were otalgia and headache in patient with myoepithelial carcinoma in parapharyngeal space. CT image showed malignant neoplasm and surrounding tissues were destroyed. Diagnosis depends on pathology and immunohistochemistry.