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CCL25和CCL28及其相应受体CCR9和CCR10 被引量：4

CCL25 and CCL28 and Their Cognate Receptors CCR9 and CCR10
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摘要 CCL25和CCL28是CC趋化因子家族成员,主要表达于胸腺树突状细胞和黏膜上皮细胞,CCL25和CCL28相应的受体分别是CCR9和CCR10,表达于T淋巴细胞和B淋巴细胞。CCL25和CCL28及其相应受体对循环IgA浆母细胞和T淋巴细胞的归巢起重要作用,而且CCL28还具有广谱的抗微生物活性。 CCL25 and CCL28, members of chemokine CC subfamily, are primarily expressed in thymic dendritic cells and mucosal epithelial cells. The cognate receptors of CCL25 and CCL28 are CCR9 and CCRI0 expressed in T and B lymphocytes. CCL25 and CCL28, with their cognate receptors, play essential roles in homing of circulating IgA secreting cells and T lymphocytes, and CCL28 also has a broad-spectrum antimicrobial activity.
作者 乔新安 朱彦彩 都军霞 范沛 林茂旺 杨国宇
机构地区 河南农业大学动物生理生化实验室 河南科技学院动物科学学院
出处 《医学分子生物学杂志》 CAS CSCD 2007年第5期458-460,共3页 Journal of Medical Molecular Biology
基金 河南省科技攻关计划项目(No.0523010500)~~
关键词 趋化因子 胸腺表达调节趋化因子 黏膜相关上皮趋化因子 chemokines CCL25 CCL28
分类号 R362 [医药卫生—病理学] Q257 [生物学—细胞生物学]
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参考文献22

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医学分子生物学杂志
2007年 第5期

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