子宫内膜异位症对体外受精-胚胎移植妊娠结局的影响

Effect of Endometriosis on Cycle Outcome of in Virto Fertilization-embryo Transfer

目的:探讨子宫内膜异位症对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法:对2003年4月至2005年12月69例子宫内膜异位症合并不孕症及同期73例输卵管性不孕症行IVF-ET的患者进行回顾性分析,子宫内膜异位症按照临床病理类型分为A、B两组,A组为卵巢型,B组为腹膜型,随机选同期输卵管性不孕患者为C组,比较A、B、C 3组间的促性腺激素(Gn)的用量、卵子数、受精率、临床妊娠率、种植率和分娩率。结果:子宫内膜异位症A、B两组使用Gn总量显著高于C组(P<0.05),获卵数显著低于C组(P<0.05),而受精率、临床妊娠率、种植率、分娩率在3组间差异无显著性。结论:子宫内膜异位症降低卵巢对超促排卵的反应性使获卵数减少,但不影响IVF-ET的妊娠结局。

Objective：To investigate the effect of enckxnetriosis on in vitro fertilization-embryo transfer （IVF-ET） outcome.Methods：In this retrospective study, 69 infertile patients with endometdosis and 73 patients with tubal-infertility undergoing IVF-ET were included. According to their clinical pathological type, 69 cases of endometriosis were divided into two groups： group A as ovarian endometriosis, group B as peritoneal endometriosis. The requiremerit to gonadotropin （Gn）, the number of oocytes, the fertilization rate, the clinical pregnancy rate, the implantation rate, and delivery rate were compared among three groups. Results：More requirements to Gn and lower number of oocytes in the endometriosis patients compared to those tubal-infertility. There were no significant difference in fertilization rate, clinical pregnancy rate, implantation rate, and delivery rate among three groups.Conclusions：Endometriosis patients present a poor-response to controlled ovarian hyperstimulation that results a decreased numbers of oocytes. Fortunately, it does not deleteriously affect the IVF-ET outcome.