头孢特伦新戊酯颗粒溶出度测定方法研究

Study on Determination Methed of Dissolution for Cefteram Pivoxil Dispersible Granules

目的:建立头孢特伦新戊酯颗粒溶出度测定方法。方法:用紫外分光光度法测定溶出量,以盐酸溶液(9→1000)为溶出介质。检测波长263 nm。结果:头孢特伦在2.4～19.2μg·ml^(-1)浓度范围内与其吸光度呈良好线性关系(r=0.999 9)。20 min取样,溶出度在90%以上(浆法)。结论:该方法操作简便,准确可靠;可用于头孢特伦新戊酯颗粒的溶出度测定。

Objective： To establish determination method of dissolution for Cefteram Pivoxil Dispersible Granules. Method： The dissolution rate were determined by UV spectrophotometry, the 0.1 mol·L^-1 bydrochloric acid solution was used as dissolution medium, the detection wavelength was 236 nm. Result： The linear ranges of cefteram was 2.4 - 19.2 μg·ml^-1 （ r = 0. 999 9）, the dissolution at 20 rain was above 90% （ paddle method）. Conclusion： The method is simple and accurate. It can be used for dissolution test of cefteram pivoxil dispersible granules.