强肌健力胶囊对烟碱型乙酰胆碱受体代谢的影响

Effect of Qiangji Jianli Capsule on Metabolism of Acetylcholine Receptor

目的：探讨强肌健力胶囊治疗重症肌无力的作用机理。方法：用小白鼠体内受体掺入和降解试验。结果：发现强肌健力胶囊治疗组在９６ｈ时的受体掺入量为９０２．５３±３７．４７ｃｐｍ／ｍｇ，而对照组为７３８．４５±３５．４１ｃｐｍ／ｍｇ（Ｐ＜０．００１）；治疗组的受体降解半衰期为５２ｈ，对照组为３８ｈ（Ｐ＜０．００１）。结论：强肌健力胶囊能加速烟碱型乙酰胆碱受体掺入隔肌细胞表面速度和减慢受体降解，使单位时间内功能性受体蓄积量增加，保持病理状态下受体代谢的动态平衡。

To explore the action mechanism of Qiangji Jianli Capsule (QJJLC) treating myasthenia gravis. methods: Imernal receptor permeation and degradation test were performed. Results: Volnme of receptor permeation in the group with QJJLC at 96 hours was 902. 50± 37. 48 cpm/mg,while that of control group 738. 45135. 41cpm/mg. Half-life of receptor degradation in treatmentgroup was 52 hours and that of control 38 hours. Their difference was very significant (P<0. 001 ). Conclusion: QJJLC could accelerate permeation of N-aectylcholine receptor to surface of diaphragm cell membrane and decelerate receptor degradation. It could also increase accumulative amounts of functional receptor in unit time and keep dynamic equilibrium of receptor metabolism in pathologic condition.