摘要
叶下珠能明显降低ＣＣｌ４引起的小鼠血清ＡＬＴ的升高，抑制肝脏ＭＤＡ的生成。叶下珠体外与大鼠肝细胞共同孵育，能抑制ＣＣｌ４所致肝细胞膜流动性降低，降低〔Ｃａ２＋〕ｉ浓度。结果提示，叶下珠保护肝脏损伤作用可能与其抗指质过氧化和膜保护作用有关。
It has been found out that the carbon tetrachloride (CCl 4) induced increase of serum glutamic pyruvic transaminase (ALT) and elevation of MDA in liver of mice are significantly lowered by Phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with Phyllanthus urinaria in vitro significantly inhibits CCl 4 induced decrease of mobility of membrane of liver cells and increase of intracellular free Ca 2+ ([Ca 2+ ]i) concentrations of liver cells. These results suggest that the anti lipid peroxidation effect and protective action of membrane of Phyllanthus urinaria may be related to its protective action against CCl 4 induced liver injuries.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1997年第2期109-111,共3页
China Journal of Chinese Materia Medica
基金
中国人民解放军青年基金
