CCL27和CCR10在寻常性银屑病皮损的表达及与PASI的相关性

Expressions of skin-specific chemokine CCL27 and its receptor CCR10 in lesions of psoriasis vulgaris and its correlation with disease activity

目的 探讨皮肤特异性趋化因子CCL27及其受体CCR10在寻常性银屑病皮损中的表达和表达强度与疾病活动性的相关性。方法 SP免疫组化染色检测20例寻常性银屑病皮损区皮损和10例正常人皮肤中CCL27、CCR10的表达，以PASI评分评价银屑病患者疾病活动性。结果 ①CCL27在20例寻常性银屑病皮损和10例正常人皮肤中表达的阳性率分别为95％和20％，两者差异有统计学意义（r=17．86，P〈0．01）；CCR10在20例寻常性银屑病皮损和10例正常人皮肤表达的阳性率分别为85％和10％，两者的差异有统计学意义（r=15．63，P〈0．01）。②CCL27和CCR10在皮损中的表达水平与PASI评分均呈明显正相关，r值分别为0．82和0．83，P值均〈0．01。结论 CCL27和CCR10的过度表达与银屑病患者的疾病活动性相关。

Objective To investigate the expressions of skin-specific chemokine CCL27 and its receptor CCR10 in lesions of psoriasis vulgaris and the relation between their expression intensity to disease activity. Methods Specimens were collected from 20 patients with psoriasis vulgaris and 10 normal human controls. The expressions of CCL27 and CCR10 were measured by streptavidin-peroxidase （ SP ） technique. Results The positivity rates of CCL27 and CCR10 were significantly higher in lesions of psoriasis vulgaris than those in normal controls （ 95% vs 20%, χ^2 = 17.86, P 〈 0.01; 85% vs 10%, χ^2 = 15.63, P 〈 0.01 ）. The expression levels of both CCL27 and CCR10 positively correlated with psoriasis area and severity index （ PASI ） of patients with psoriasis vulgaris （ r = 0.82, 0.83 respectively, both P 〈 0.01 ）. Conclusion These results suggest that the overexpression of CCL27 and CCR10 may be related to the disease activity of psoriasis vulgaris.