烟酰胺和N-乙酰葡萄糖胺改善色斑效果观察

The effect of niacinamide and N-acetylglucosamine on hyperpigmentation

目的:比较含烟酰胺和N-乙酰葡萄糖胺的护肤品在改善色素沉着方面的效果。方法:双盲、基质对照人体试验。采用REAL3.0系统采集所有图像,用相关软件分析色斑面积百分比、L*a*b值、黑素相关的色斑面积百分比、平均黑素含量(灰度)和黑素相关的皮肤颜色均匀度;Chromameter测量非色斑部位皮肤颜色改变;由皮肤科专家分析使用护肤品前后照片改善情况和受试者自我比较进行主观评价。结果:与基质相比,含烟酰胺和N-乙酰葡萄糖胺的护肤品可以抑制色斑面积的增加,减轻紫外线引起的肤色加深和肤色不均匀。结论:正常人皮肤对含烟酰胺和N-乙酰葡萄糖胺的护肤品有良好的耐受性,与基质相比,该护肤品有一定的减轻色素沉着的效果。

Objective： The purpose of this study is to verify the depigmentation action of a skin care product containing niacinamide and N-acetylglucosamine （N/NAG） on facial hyperpigmentation. Methods： This study was a vehicle-controlled, full-face, parallel group comparison in Chinese female subjects with facial hyperpigmentation. All pictures of all subjects were taken by REAL 3.0 system, and used the REAL 3.0 system to analyze spot area fraction, L＊a＊b value, NC2 melanin spot area fraction, NC2 melanin gray scale and NC2 melanin evenness. A Chromameter was used to measure the L＊a＊b value for nonlesional area. Expert assessment on color pictures of the subjects before and after the usage of the product ,and self assessment questionnaires were also used. Results： Compared to the vehicle control, the N/NAG product provided significant benefits on reducing spot area fraction, minimized skin darkening and yellowing, increased skin color evenness and minimized the NC2 melanin gray scale. Conclusions： The N/NAG product was well tolerated. In comparison with the vehicle control, it produced a significant improvement in skin color and hyperpigmentation.