静脉用蔗糖铁治疗血透患者肾性贫血的临床观察

Clinical Observation of the Treatment in the Patients with Renal Anemia on Hemodialysis Through Iron Sucrose Injection

目的观察静脉用蔗糖铁与口服琥珀酸亚铁治疗血液透析患者肾性贫血的疗效。方法将64例患者随机分为静脉组和口服组,分别用静脉注射蔗糖铁和口服琥珀酸亚铁进行治疗8周。监测治疗前/后血红蛋白(HGB),红细胞数量(RBC),血细胞压积(HCT),血清铁蛋白(SF)的变化。结果治疗后与治疗前比较,口服组:HGB上升(10.2±1.3)g/L,RBC上升(1.1±0.24)×1012,HCT上升(3.6±0.67)%,SF上升(130.5±31.5)ug/L;静脉组:HGB上升(18.2±3.8)g/L,RBC上升(1.4±0.37)×1012,HCT上升(5.9±0.83)%,SF上升(421.6±64.8)ug/L。静脉组各项上升幅度与口服组上升幅度经统计学处理有显著差异。结论静脉注射蔗糖铁较口服琥珀酸亚铁疗效显著。

Objective To observe the effect of iron sucrose injection and oral ferrous succinate tablets at treatment in patients with renal anemia on hemodialysis. Methods 64 cases were divided at random into vein group and oral group：the vein group was treated by iron sucrose injection;oral group was treated by ferrous succinate tablets. The cure period is 8 weeks. Monitor the rise degree of the hemoglobin（ HGB）, the red blood cell（ RBC）, hematocrit （HCT） ,and serumferritin（SF）. Results Through the comparison between two groups before and after the treatment oral group：HGB rise（10.2 ± 1.3） g/L, RBC rise （1. 1 ±0.24） × 10^12, HCT rise （3.6±0. 67）% ,SF rise （130.5±31.5） ug/L;the vein group： HGB rise （18.2±3.8） g/L, RBC rise （1.4 ±0.37） × 10^12,SF rise （421.6±64.8） ug/L. The rise degree is significantly different between the vein group and oral group by statistical treatment. Conclusion The effect of iron sucrose injection treatment in patients with renal anemia on hemodialysis is effective than taking ferrous succinate tablets and fewer side effects came out.