双环醇联合利巴韦林治疗丙型肝炎肝硬化的疗效观察

Clinical Observation on Bicyclol Combined with Ribavirin in the Treatment of Hepatitis C Hepatocirrhosis

目的探讨双环醇片联合利巴韦林治疗丙型肝炎肝硬化的临床疗效。方法对照组(13例)给予护肝、支持及对症治疗,观察组(19例)在此基础上加用双环醇和利巴韦林治疗,疗程均为24周。结果治疗为24周时,观察组血清HCV-RNA转阴7例(36.84%),对照组0例,二者比较差异显著,x2=4.16,P<0.01;观察组有15例(78.95%)血清ALT恢复正常,对照组4例(30.77%),二者比较差异显著,x2=5.56,P<0.05;观察组治疗前后ALT值分别为(133±56)u/L和(52±34)u/L,二者比较差异显著,t=7.637,P<0.05。结论双环醇联合利巴韦林治疗丙型肝炎肝硬化降酶效果显著,且有一定的抗病毒疗效,值得临床应用。

Objective To discuss the clinical observation on bicyclol combined with ribavirin in the treatment of hepatitis C hepatocirrhosis. Methods The control group（ 13 cases） were offered protection of liver, support and expectant treatment. Observation group（ 19 cases） were treated with bicyclol combined with ribavirin based on the above therapy, which lasted for 24 weeks. Results At 24th week there are 7 cases（36.84% ） whose serum HCV- RNA converted to negative in observation group and no case in control group, through the comparison the difference is distinct between the two groups, x^2 = 4. 16,P 〈 0.01 ; there are 15 cases（78.95% ）whose serum ALT returned to the normal in observation group and 4 cases（30.77% ） in control group, the difference is distinct between them,x^2 = 5.56, P 〈 0.05 ;ALT are （133 ± 56）u/L and （52 ± 34）u/L respectively before and after the treatment in observation group, the difference is distinct through the comparison, t = 7. 637, P 〈 0.05. Conclusion The effect of reducing enzyme is distinct in the treatment of hepatitis C hepatocirrhosis through bicyclol combined with ribavirin, which is also antivirotic, so it is worthwhile applying in clinic.