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New process for preparing benazepril precursor

New process for preparing benazepril precursor
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摘要 The present work relates to a new synthesis process for the preparation of 3-[(1-ethoxycarbonyl-3-phenylpropyl)-amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester(EPTAB),the precursor of benazepril HCl.The reaction conditions were optimized.The diastereomeric products were separated by flash column chromatography.The structures of the products were characterized with IR and NMR. The present work relates to a new synthesis process for the preparation of 3-[（1-ethoxycarbonyl-3-phenylpropyl）-amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester（EPTAB）,the precursor of benazepril HCl.The reaction conditions were optimized.The diastereomeric products were separated by flash column chromatography.The structures of the products were characterized with IR and NMR.
作者 Kafssi Hassan 王涛 王芳 万平玉
机构地区 Department of Chemistry
出处 《化工学报》 EI CAS CSCD 北大核心 2007年第10期2558-2560,共3页 CIESC Journal
关键词 制备 前体 血管紧缩素转换酶 盐酸贝那普利 benazepril HCl EPTAB preparation
分类号 TQ463 [化学工程—制药化工]
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参考文献10

  • 1Urbach H,Henning R.A favourable diastereoselective synthesis of N-(1-S-ethoxycarbonyl-3-phenylpropyl) -S alanine.Tetrahedron Lett.,1984,25 (11):1143-1146
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  • 7Thaper Rajesh Kumar,Kumar Yatendra.Process for the preparation of benazepril:WO,02076375.2002
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化工学报
2007年 第10期

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