巨细胞病毒感染与急性心肌梗死关系的研究

Relation between cytomegalovirus infection and acute myocardial infarction

目的探讨巨细胞病毒(cytomegalovirus,CMV))感染与急性心肌梗死(acute myocardial infarction,AMI)之间的关系。方法采用酶联免疫法(ELISA)检测72例AMI患者与79例正常对照组血清中CMV抗体水平,同时检测两组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、可溶性血管细胞间黏附分子-1(sVCAM-1)、超敏C-反应蛋白(hsCRP)水平。结果AMI组巨细胞病素IgG抗体阳性率(61.11%)显著高于对照组(43.04%,P<0.05)。AMI组IL-6(69.08±108.29)、TNF-α(36.79±5.78)、sVCAM-1(30.03±25.86)、hsCRP(23.80±33.44)水平与对照组(22.91±17.37、2.11±3.32、5.53±5.37、2.10±1.79)比较差异有统计学意义(P<0.01)。结论CMV感染可能通过激发和加重冠状动脉内炎症反应,参与动脉粥样硬化、AMI的病理过程。

Objective To study the relation between cytomegalovirus infection and acute myocardial infarction （ AMI）. Methods Cytomegalovirus IgG antibodies of 72 patients with AMI and 79 normal controls were measured by ELISA. The levels of interleukin - 6 （ IL - 6 ） , tumor necrosis factor - α （ TNF - α） , soluble vascular cell adhesion molecule - 1 （ sVCAM - 1 ） and high sensitivity C - reactive protein （hsCRP） were also determined. Results The positive rates of CMV IgG antibody（61.11% ）in AMI group were significantly higher than those in control （ 43.04%, P 〈 0. 05 ）. The concentrations of IL-6（69.08 ± 108.29）, TNF- α（36.79 ±5.78）, sVCAM- 1 （30.03 ±25. 86） and hsCRP （ 23.80 ± 33.44） in the AMI group were all higher than those（ 22.91 ±17.37, 2.11 ± 3.32, 5.53 ±5.37, 2.10 ± 1.79 ） in the control group （all P 〈 0. 01 ）. Conclusion There is significant correlation between cytomegalovirus infection and AMI. Cytomegalovirus infection may be involved in the pathogenesis of atherosclerosis and myocardial infarction by inducing and accelerating coronary artery inflammation.