肠功能障碍的发病机制认识

Cognition of the nosogenesis of intestinal dysfunction

肠道是维持机体营养、免疫的重要器官,同时也是体内最大的"储菌库"和"内毒素库"。肠道屏障可因各种刺激而改变,使肠免疫功能受到抑制,肠内细菌易位,内毒素、细菌、抗体介质不断进入血液和淋巴液,导致多种炎症介质释放,引发和加重失控性炎症反应综合征(SIRS),而SIRS的发生更加重了肠道损伤,形成恶性循环。肠黏膜屏障、细菌易位、胃肠激素、细胞凋亡等因素与肠功能障碍的发病密切相关。

Intestine is an important organ that maintains the nutrition and the immunity in the body, and it is also the biggest bacterial and endotoxic storeroom. Alteration of the intestinal barrier caused by various stimulations can inhibit the intestinal immunologic function and cause bacterial translocation, then the endotoxin, bacteria and antibody mediators enter the blood and lymph, which causes the release of various inflammatory mediators, then aggravates SIRS. Intestinal injury is more severe because of SIRS. All of those correlated factors interacting with each other form a vicious circle. Intestinal dysfunction have a intimate correlation with some factors, such as intestinal harrier, bacterial translocation, gastrointestinal hormones , apoptosis, etc.