病原体：驱动了MHC多样性

Do Pathogens Drive MHC Diversity

主要组织相容性复合体（major histocompatibility complex，MHC）因其在免疫系统中的重要作用而受到越来越多的关注。人类的MHC称人白细胞抗原（human leukoecyte antigen，HLA）系统，是迄今所知在人类基因组中最复杂的遗传多态性系统。目前的研究认为病原体是驱动和维持MHC高度多样性的主要选择压力，该文就这一领域的研究进展作一综述。

For the importance in the immune system,the major histoeompatibility complex（MHC） has been paid more and more attention. In human,MHC known as the human leukoeyte antigen（HLA） region is the most polymorphic gene cluster in human genome. The purpose of this paper is to review the evidence for the role of pathogens in the drive and maintenance of MHC polymorphism.