重型颅脑外伤并发下呼吸道感染铜绿假单胞菌的耐药性分析

Lower respiratory tract infection by pseudomonas aeruginosa in severe brain trauma:an analysis of drug sensitivity status

目的了解重型颅脑损外伤患者并发下呼吸道感染铜绿假单胞菌的临床特点及药敏情况,为临床使用抗生素提供依据。方法回顾我院近四年来重型颅脑损伤合并下呼吸道感染铜绿假单胞菌及药敏资料。结果重型颅脑外伤患者并发下呼吸道感染中,铜绿假单胞菌占17.5%,肺炎克雷伯氏菌占11.7%,鲍曼溶血不动杆菌占10.7%,金黄色葡萄球菌(7.77%)。药敏试验结果显示铜绿假单胞菌对抗生素的耐药依次为亚胺培南(13%)、环丙沙星(14.8%)、其余均>15%。结论铜绿假单胞菌已成为重型颅脑损伤并发下呼吸道感染的主要菌种,应根据药敏结果慎重用药。

Objective To investigate the clinical characteristic and drug sensitivity status of lower respiratory tract infection by pseudomonas aeruginosa（ PA ） in severe brain trauma, in order to provide essential basis for the treatment with antibiotics. Methods Retrospective survery respiratory tract infection by PA in severe brain trauma in our hospital nearly four years,including,the drug sensitivity result was conducted. Results Bacilli from severe brain trauma patients with lower respiratory infections diseases were PA（ 17.5% ） , klebsiella pneumonieae （ 11.7% ） , aeinetobacter bauamnnii（ 10.7% ） , staphylococcus aureus （7.77%）. The drug sensitivity tests results showed that PA was resistance to imipenenl（ 13% ）, ciprofloxacin（ 14.8% ）, to oth- er drugs was greater to 15%. Conclusion PA has becoming the major bacteria responsible for lower respiratory tract infection in severe brain trauma. Selection of antibiotics for treatment should be base on the results of drug susceptibility.