喷雾干燥法制备陈皮挥发油微囊的影响因素考察

Influence factors on preparation of citrus volatile oil microcapsules by spray drying technique

目的探索喷雾干燥技术对制备陈皮挥发油微囊成型性的影响。方法以阿拉伯胶为囊材,采用喷雾干燥法制备陈皮挥发油微囊。单因素考察进风温度、进样速度、喷雾空气流量以及排风容积。采用均匀设计对工艺参数进行优选。结果最佳条件为囊材阿拉伯胶与药物比为0.9,增塑剂微粉硅胶与囊材比为0.15,进风温度145℃,进样速度18mL/min,喷雾空气流量40L/h。制得的微囊表面较光滑,平均包封率达84.50%,平均载药量为28.32%。结论所选用的喷雾干燥法优化条件比较合理,能够较显著的提高挥发油微囊的稳定性。

Objective To investigate the influence factors on preparation of citrus volatile oil microcapsules by spray drying technique. Methods The citrus volatile oil microcapsules were prepared by spray drying technique with arabic gum as coating material. The temperature of aeration, injection speed, spray rate of flow, and exhausting volume were observed by single factor and the technical parameters were optimized by uniform design. Results The optimum condition including ratio of drug to coating material （0. 9）, plasticizer to coationg material （0. 15）, the temperature of aeration （145℃）, injection speed （18 mL/min）; and spray rate of flow （40 L/h）. The microcapsules prepared by optimum conditions were smooth and possessed average encapsulation efficency in 84.50%, average drug loading in 28.32%. Conclusion The optimum conditions are chosen reasonably, which can increase the stability of citrus volatile oil microcapsules significantly.