酮替芬在小儿哮喘中的应用

The efficacy of ketotifen for the treatment of childhood asthma

目的评价酮替芬在治疗小儿哮喘中的安全性和有效性。方法计算机检索Cochrane中心对照试验记录、MEDLINE、CINAHL、EMBASE、CBMdisc、CNKI相关的随机和半随机对照研究。结果共纳入21篇随机对照研究,质量等级为B或C。结论酮替芬对于小儿哮喘有较好的控制效果,可以明显减少支气管扩张剂以及口服糖皮质激素的应用。

Objectives To evaluate the efficacy and safety of ketotifen for treating children with asthma. Methods Medical records of childhood asthma were searched from databases including the Cochrane Library, MEDLINE, CINAHL, EMBASE, CBMdisc and CNKI. Randomized controlled trials and quasi-randomized controlled trials were included. Results Twenty-one randomized controlled trials were analyzed. Quality grade was B or C. Conclusions Keto- tifen has a good therapeutic effect on childhood asthma and greatly reduce the administration and dosage of bronchiectasia agents and oral corticosteroids.