肾病患者血清B因子检测的临床意义

Clinical Significance of Nephrosis Serum BF Detecting

目的探讨肾病患者血清B因子(BF)检测的临床意义。方法对146例不同肾病患者进行了BF水平的检测,对其中28例狼疮肾患者同时作抗核抗体(ANA)、抗ds-DNA及肾功能指标的对比分析。结果各肾病组BF水平由低到高依次为肾病综合征和慢性肾衰<<急性肾炎<慢性肾炎和狼疮肾<<健康对照组("<<"表示P<0.01;"<"表示P<0.05;无比较者表示P>0.05)。狼疮肾患者中ANA阳性组与阴性组,抗ds-DNA阳性组与阴性组之间BF水平均无明显差别(P>0.05),但肾功能受损严重者与肾功受损不明显者有显著差别(P<0.01)。结论动态地监测血清BF对急、慢性肾炎及狼疮肾疗效的观察和预后的判断有一定的指导意义。

Objective To investigate the clinical significance of nephritic serum BF detecting. Methods 146 nephritics had been tested BF, 28 lupus nephritis in which had been tested ANA, Anti-ds-DNA and renal function indexs comparative analysis at the same time. Results BF level of the nephrosis groups from low to high was：nephrotic syndyome and chronic renal failure〈〈 acute nephritis 〈chronic nephritis and lupus nephrosis〈〈healthy contrast group（＂〈〈＂ means P〈0. 01 ;＂〈＂ means P〈0. 05 ;others P〉0. 05）. While in lupus nephritis ,BF levels both in ANA positive group ,negative group and in Anti-ds-DNA positive group,negative group had no obvious difference （P〉0. 05）,But there was marked difference in renal function seriously damaged group and non-evident damaged group（P〈0. 01）. Conclusion It is of a certain directive importance to make dynamic analysis on serum BF for acute or chronic nephritis and lupus nephrosis to make curative effect observation and prognosis judgment.