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双膦酸盐对成骨细胞活性的影响 被引量：2

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摘要 骨组织代谢活跃，成骨细胞和破骨细胞是骨代谢过程中重要的核心细胞。骨代谢过程中，破骨细胞吸收旧骨，成骨细胞形成新骨，这种骨质的新陈代谢称为骨转换（bone—turnover）。在骨转换过程中，成骨细胞被激活，其主要功能是合成、分泌胶原与糖蛋白，形成骨基质，并通过碱性磷酸酶等多种酶介导骨组织矿化。其分泌胶原95％为Ⅰ型胶原蛋白。当破骨细胞被激活，其分泌多种酸及多种酶，
作者 白晓冬 郭艾
机构地区 首都医科大学附属北京友谊医院骨科
出处 《中国骨肿瘤骨病》 2007年第5期311-313,共3页 Chinse Journal Of Bone Tumor And Bone Disease
关键词 成骨细胞活性 双膦酸盐 破骨细胞吸收 骨组织代谢 分泌胶原 Ⅰ型胶原蛋白 代谢过程 碱性磷酸酶
分类号 R96 [医药卫生—药理学]
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参考文献7

二级参考文献61

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共引文献36

同被引文献23

  • 1宇空,王景云.阿仑膦酸钠抑制骨吸收的研究进展[J].国外医学（口腔医学分册）,2006,33(1):36-38. 被引量：16
  • 2孟健,郑梁元.柱前衍生化-高效液相色谱法测定阿伦膦酸钠微乳中阿伦膦酸钠的含量[J].药物分析杂志,2007,27(9):1456-1458. 被引量：8
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  • 10郝二军,程传玲.阿仑膦酸钠合成工艺的改进[J].华西药学杂志,2009,24(1):54-55. 被引量：1

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中国骨肿瘤骨病
2007年 第5期

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