慢性阻塞性肺疾病BODE评分与疾病严重程度关系的研究

BODE score in chronic obstructive pulmonary disease(COPD)and its relation to disease severity

目的比较BODE评分及第一秒用力呼气容积(FEV1)在慢性阻塞性肺疾病(COPD)患者临床评价中的作用。方法对2004年9月至2006年2月首都医科大学宣武医院呼吸科就诊的41例稳定期COPD患者FEV1、BODE评分、COPD急性加重(AECOPD)次数、AECOPD持续时间、因AECOPD的住院次数、住院时间及住院时痰培养阳性率进行测定,采用SPSS11.0统计软件进行统计分析。结果FEV1≥1L组及BODE评分<5分组,AECOPD次数、AECOPD持续时间、因AECOPD的住院次数、住院时间及住院时痰培养阳性率,均好于FEV1<1L组及BODE评分≥5分组,差异有显著性意义(均P<0.05)。相关分析显示,FEV1与AECOPD次数、AECOPD持续时间、因AECOPD的住院次数、住院时间及住院时痰培养阳性率呈显著负相关,均P<0.01;BODE与AECOPD次数、AECOPD持续时间、因AECOPD的住院次数、住院时间及住院时痰培养阳性率呈显著正相关,P<0.01。结论BODE评分系统和FEV均能评价COPD患者的病情严重程度,以BODE评分系统更为全面及准确。

Objective To compare FEV1 with BODE in evaluating COPD. Methods Forty-one stable COPD patients, 23 males and 18 females,with mean age of 58. 8 years,were evaluated for FEV1 and BODE scores,the number and duration of acute exacerbations of COPD （AECOPD）, number of admissions and duration of hospitalization caused by AECOPD, and sputum culture. All data were statistically analyzed with SPSS 11.0 for Windows. Results There was a remarkable difference in disease severity between the group with FEV1 ≥ 1 L and BODE score 〈 5 and the group with FEV1 〈 1 L and BODE score≥5, in regard to AECOPD duration and number of attacks, number of admissions, length of hospitalization and positive sputum cultures, P 〈 0. 05. FEV1 had a negative correlation, while BODE score had a positive correlation with the above-mentioned parameters,P 〈 0. 001. Conclusion Both FEV1 and BODE score can be used to evaluate disease severity in COPD ,however, BODE score is better.