红花注射液联合激素和环磷酰胺治疗难治性肾病综合征

Clinical Study of Honghua Injection Plus Prednisone and Cyclophosphamine Treatment on Refractory Nephrotic Syndrome

[目的]观察红花注射液联合激素和环磷酰胺治疗难治性肾病综合征的临床疗效观察。[方法]观察38例难治性肾病综合征患者用中药制剂红花注射液结合西药治疗前后肾功能、肝功、血脂、血常规、24h尿蛋白的对比。[结果]总有效率92.1%,缓解率73.68%(28例),部分缓解18.42%(7例),无效7.89%(3例)。[结论]红花注射液联合西药治疗难治性肾病综合征,减少激素的用量及副作用,增强疗效,缩短疗程,减少复发,防止反弹。

[Objective]To investigate the therapeutic effect of Honghua injection plus prednisone and cyclophosphamine on refractory nephrotic syndrom. [Methods] 38 patients with refractory nephrotic syndrom were given intravenous Honghua and cyclophosphamine plus oral prednisone. Serum total cholesterol, triglyceride, liver and renal function, blood routine test, 24h protennuria were observed.[Results] Total effective ratio was 92.1%.Cure ratio was 73. 68%. Partly cure ratio was 18. 42% and ineffective ratio was 7.89%. [Conclusions] Patients with refractory nephrotic syndrom were treated by Honghua injection plus prednisone and cyclophosphamine, which could reduce the application of prednisone, its side effects and enforce its therapeutic effect. What is more, this treatment could lessen therapeutic process, prevent relapse and recoil, protect effectively the retreat syndrom of prednisone as well.