痤疮患者局部皮肤雄激素受体及性激素与中医相关证型的关系

Relationship among skin AR,sexual hormones & TCM syndromes in acne vulgaris

目的:探讨痤疮患者局部皮肤雄激素受体(AR)及性激素与中医相关证型的关系,从激素受体的角度揭示痤疮发生的机制。方法:选择70例典型面部痤疮患者作为观察对象,15例健康者作为对照组,采用皮肤雄激素受体、血清性激素、中医辨证为指标。结果:男、女性患者的睾酮(T)值均高于对照组(P<0.01、P<0.05);患病部位的局部AR阳性百分率显著高于非患病部位(P<0.01),局部皮肤的AR与血清雄激素水平无相关性(P>0.05);不同证型组AR阳性率以肾虚火旺型最高,但统计无显著差异(P>0.05)。结论:痤疮发病不仅与血清T升高有关,同时与局部毛囊上皮细胞AR有关。T与AR是痤疮异证同病的物质基础。

Objective： To approach the relationship among skin androgen receptor（AR）,sexual hormones and TCM syndromes in acne vulgaris,and to reveal the mechanism of acne vulgaris from the view point of hormone receptor.Methods： The indexes of AR,sexual hormones and differentiation of TCM syndrome were used in 70 patients with acne vulgaris,and 15 healthy persons as control group.Results：①Compared with control group,the testosterone in both male and female patients were higher than that in control group（P〈0.01,P〈0.05）.②The positive rate of AR in Par aff skin was higher（P〈0.01）than that of unaffiliated part,but it was not co-related to blood serum androgen（P〉0.05）.③The positive rate of AR in the group with flaming fire due to kidney deficiency syndrome was the highest,while it had no significant difference（P〉0.05）.Conclusion： The mechanism of acne is not only related to the ascending of T,but also related to AR in follicular epithelial cells.The T and AR are the material basis of different syndrome with same disease in acne.