摘要
目的观察肺纤方与强的松对照抗大鼠肺纤维化的作用。方法采用气管内注入博莱霉素制造大鼠肺纤维化模型,观察造模后14、28、45 d模型组、假手术组、肺纤方组、强的松组肺组织匀浆液中层粘连蛋白及Ⅰ、Ⅲ型胶原含量。结果肺纤方显著减轻肺纤维化大鼠层粘连蛋白及Ⅰ、Ⅲ型胶原的含量。结论肺纤方有显著抗大鼠肺间质纤维化作用。
Objective To observe the effect of Feixian Recipe on pulmonary fibrosis in rats. Methods Rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin. On day 14, 28 and 45, the contents of laminin,collagen Ⅰ and Ⅲ in lung tissue homogenate in model group, sham operated group, Feixian group and prednisone group were measured. Results The contents of laminin, collagen Ⅰ and Ⅲ were decreased significantly by Feixian Recipe. Conclusion Feixian Recipe has significant therapeutic effect on bleomycin induced pulmonary fibrosis in rats.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2007年第9期608-610,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
北京市科委课题(No.Y0204003041011)
