补肾调脂汤治疗高脂血症临床观察

Clinical observation on treating hyperlipemia with Bushentiaozhi Decoction

目的观察补肾调脂汤治疗肾虚血瘀型高脂血症的临床疗效和安全性及其与c-反应蛋白的关系。方法将符合诊断标准的原发性高脂血症患者60例随机分为治疗组(A)和脂必妥对照组(B),疗程6周,观察2组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)的变化,及其2组血脂疗效的比较以及TC、TG与CRP的关系。结果6周后TC、TG、HDL-C、LDL-C、CRP A、B组治疗前后及2组间均有统计学差异。2组血脂控制疗效对比P<0.05,CRP与TC、TG存在正相关关系。结论用补肾调脂汤治疗肾虚血瘀型高脂血症有较好的临床效果,且安全性较高。

Objective To observe the clinical therapeutic effect of Bushengtiaozhi Decoction on hyperlipemia with renal deficiency and blood stasis and its security, and the relationship between curative effect and C-reactive protein. Method Sixty cases of patients with essential hyperlipidemia were randomly divided into treatment group and Zhibituo control group with 6 weeks of treatment. Changes of total cholesterol （ TC ）, triglyeride （ TG ）, high density lipoprotein-cholesterol （ HDL-C ）, low density lipoprotein-cholesterol（ LDL-C ） and C-reactive protein （CRP） were observed. The relationship between TC or TG and CRP was analyzed. Results There were significant differences in TC, TG , HDL-C, LDL- C and CRP between pretherapy and post-treatment, and between treatment group and control group. CRP was positively related with both TC and TG. Conclusion Bushengtiaozhi Decoction has better clinical therapeutic effect on hyperlipemia with renal deficiency and blood stasis and has higher security.