摘要
碳酸酐酶抑制剂(CAIs)作为药物具有广泛的生物活性,如抗青光眼、利尿、抗肿瘤、抗癫痫、抗风湿、降血糖等。近几年,新一代抗青光眼磺胺类CAIs已经取得很大的研究成果,抗肿瘤磺胺类CAIs的研究也日益活跃,发展极为迅速。现综述磺胺类CAIs在抗青光眼和抗肿瘤领域的研究进展。
Carbonic anhydrase inhibitors (CAIs) as drugs display extensively biologic activities such as antiglaucomatous, diuretic, antitumor, antiepileptic, antiarthritic, hypoglycemic ones. In recent years,the new generation of sulfonamides-type CAIs used for antiglaucoma have gained a lot of achievements. Much work is being focused on sulfonamide-type CAIs as antitumor drugs, the research is increasingly active, and the progress is very quick. This paper reviewed the recent advance of sulfonamide-type CAIs in antiglaucoma and antitumor field.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第18期1438-1444,共7页
Chinese Journal of New Drugs
基金
国家人事部重点项目(2002-99)
教育部留学回国人员启动金(2004-527)
重庆市科委项目(2005BB5102)
西南大学人才引进基金(SWUB2006018)
西南大学高新技术培养基金(XSGX0602)
关键词
磺胺
碳酸酐酶抑制剂
抗青光眼
抗肿瘤
sulfonamide
carbonic anhydrase inhibitor
antiglaucoma
antitumor