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影响聚酯微球中药物释放的因素 被引量：1

Factors affecting the drug release of PLA and PLGA microspheres
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摘要 聚酯材料因其原料易得、容易加工、生物相容性好、具有可生物降解性等优点,已经成为当今药物载体材料中的一大研究热点。现综合国内外的有关报道对可生物降解聚酯材料作为药物载体制备微球制剂的研究进展进行了综述。针对目前限制聚酯材料微球制剂临床应用存在的问题,从聚合物、药物、制备工艺、附加剂、辐射灭菌5个方面对影响聚乳酸(PLA)和聚乳酸乙醇酸共聚物(PLGA)缓释微球中药物释放的因素进行了重点介绍,为研究聚酯微球中药物的释放提供思路。 The research of polyester materials has become a hot spot in modern pharmaceutics, because of their availability, easy to processing, fine biocompatibility and biodegradability. The researches of preparation and drug release characteristics of poly lactate acid （PLA） and poly lactate glycollic acid（PLGA） microspheres for the drug delivery system are summarized. It focuses on the recent developments in resolving the existent problems of clinic, such as controlled release and initial burst release. This review presents advances of factors influencing the microspheres drug release in polymer,drug, preparation, supplemental agent and radiation sterilization, which may have significant implications for the research on the microspheres drug release.
作者 杨阳 高永良
机构地区 军事医学科学院毒物药物研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2007年第18期1458-1463,共6页 Chinese Journal of New Drugs
关键词 微球 突释 控释 聚乳酸 聚乳酸乙醇酸共聚物 microspheres initial burst release controlled release poly lactate acid （PLA） poly lactate glycollic acid（PLGA）
分类号 R944.9 [医药卫生—药剂学]
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参考文献37

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中国新药杂志
2007年 第18期

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