三维适形放疗加希罗达对晚期胰腺癌止痛效果的研究

EFFICACY OF THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY COMBINED WITH XELODA FOR THE PAIN RELIEF OF ADVANCE PANCRATIC CARCINOMA

目的：观察三维适形放疗联合希罗达同步治疗中晚期胰腺癌疼痛的疗效。方法：28例中晚期胰腺癌患者随机分为两组,综合组14例,采用三维适形放疗的同时给予希罗达同步化疗。放疗开始的第1d开始口服希罗达,每日1000mg/m2,bid.连用14d,停药7d,21d为一周期,至少用药2个周期以上。单放组14例,单独应用三维适形放疗。两组病人照射剂量相同（45~56Gy,1.8~2Gy/次,5次/周）。结果：综合组和单放组疼痛缓解率分别为85.7%、42.9%,疼痛改善持续时间分别为137d、102d。两组疼痛缓解率和疼痛改善持续时间有统计学差异（P〈0.05）。中位生存期综合组（6.8个月）较单放组（4.7个月）延长（P〈0.05）。结论：三维适形放疗联合希罗达可以改善晚期胰腺癌疼痛症状,延长生存期。希罗达可能有放射增敏作用。

To observe the clinical efficacy CRT）combined with xeloda for pain relief of advanced pancreatic carcinoma were randomized into two groups： of three-dimensional conformal radiotherapy （ 3 D- pancreatic carcinoma. Methods： 28 patients with combined group, on the basis of 3D-CRT, 14 pa- tients received oral Xeloda at 1000 mg/m2, twicedaily for 14 days followed by 7-day rest period and repeated in every three week intervals for more than two cycles; control group, 14 patients received 3D- CRT alone. Radiation given was similar in the two groups of patient （45 - 56 Gy, 1.8 - 2.0 Gy/f, 5 f/ w）. Results ： The pain remission rate in combined group and control group were 85.7% and 42.9% respectively. The median time of remission in combined group and control group were 137 d, 102 d respectively. Both remission rate and period of abdominal pain showed significant difference between the two groups （ P 〈 0.05 ）. The median survival time were 6.8 months and 4.7 months respectively （ P 〈 0. 05 ）. Conclusion： 3D-CRT combined with xeloda for treatment of advanced pancreatic carcinoma may relieve pain and prolong survival time. Xeloda may have radiosensitization.