抗心磷脂抗体与老年高血压危险度分层的关系

The relationship between anticardiolipin antibody and elderly patients with essential hypertension

目的通过观察不同严重程度(即不同危险度分层)的老年高血压患者血清中抗心磷脂抗体(ACLA)水平及D-二聚体(D-D)的变化,旨在了解ACLA在高血压发生发展中的临床意义。方法采用酶联免疫吸附法检测年龄≥60岁的120例高血压患者和30例健康者以及20例年龄<60岁健康者的ACLA和D-D水平,对不同危险度分层的老年高血压病患者上述指标进行比较。结果老年高血压中危、高危、极高危组的ACLA和D-D水平与健康组、低危组比较明显升高(P<0.05,P<0.01),低危组与健康对照组的ACLA和D-D水平比较无统计学差异(P>0.05),年龄≥75岁与<75岁的两组健康者比较ACLA和D-D水平比较有统计学差异(P<0.05)。结论高血压患者可能存在自身免疫,ACLA的测定对预测高血压病情轻重及并发症发生有一定的临床意义。

Objective To study anticardiolipin antibody （ACLA） and D-dimer （D-D） in elderly patients with essential hypertension （EH） to understand the clinical significance of ACLA in EH. Methods The levels of ACLA and D-D were measured by enzyme linked immunoabsorbent assay in 120 EH patients aged≥60 years and 30 healthy controls to compare in the EH patients among different risk stratification. Results The concentration of ACLA and D-D were significantly higher in patients with risk, higher risk and very high risk group than those in healthy control group and patients with low risk group （P 〈0. 01 ,P 〈0. 05）. There were no significant differences in ACLA and D- D between the patients with low risk group and healthy control group （ P 〉 0.05）. There was significant difference in ACLA and D-D levels of the healthy ones between age 375 years and age 〈 75 years （ P 〈 0.05 ）. Conclusions The EH patients might have autoimmunity. The detection of ACLA could play certain clinical role in predicting pathogenetie condition and complication of EH.