心房颤动15年间单中心回顾性分析

Retrospective analysis of hospitalized patients with atrial fibrillation in single center in 15 years

目的回顾分析我院15年中心房颤动患者的病因、临床资料及药物治疗变化差异。方法将850例心房颤动患者,按时间段分成A组(374例)和B组(476例),分别对两组患者住院病历进行回顾性分析及比较。结果B组年龄>75岁患者的比例显著高于A组(P<0.05),心房颤动病因主要是高龄、冠心病、风湿性瓣膜病及高血压。与A组比较,B组患者胺碘酮的使用有下降的趋势(P<0.05),β受体阻滞剂和华法林的应用显著上升(P<0.05)。患者发生栓塞合并症显著降低(P<0.05)。结论15年间,住院的心房颤动患者治疗方案有较大的变化,但较指南的要求仍有距离。

Objective To evaluate differences of general conditions, etiology, pharmaceutical therapy of patients with atrial fibrillation in 15 years in our hospital. Methods 850 patients were admitted during 1991-1996（group A） and 2001-2006（group B）. The hospital records were analyzed retros pectively and compared between the 2 groups. Results The proportion of patients with advanced age was higher in group B than in group A（ P 〈0.05）. Common causes of atrial fi brillation were advanced age, coronary heart disease, rheumatic valvar disease and hypertension. Compared with group A, the use of β-blocker and warfarin significantly increased （ P 〈0.05）, but the use of amiodarone significantly decreased in group B（ P 〈0.05）. The embolism complication was significantly decreased in group B（ P 〈0.05）. Conclusions This study showed that in 15 years, the medical therapy for atrial fibrillation has changed greatly, but there is still a distance to the requirement of guidelines for the management of patients with atrial fibrillation.