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未折叠蛋白反应与多发性骨髓瘤的治疗 被引量：2

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摘要 内质网（endoplasmic reticulum，ER）是真核细胞中负责分泌性蛋白折叠和组装的主要细胞器。当细胞在内外源因素刺激下，ER中未折叠或错误折叠的蛋白增多，出现ER应激（ERstress），继而引发未折叠蛋白反应（unfolded proteinre．sponse，UPR），可以促进分子伴侣等靶基因的转录，减少蛋白质翻译，并通过内质网相关蛋白降解（ER—associated degra．dation，ERAD）途径，将未折叠蛋白经泛素一蛋白酶体系统降解，使细胞在应激状态下存活；
作者 袁振刚 侯健
机构地区 第二军医大学附属长征医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2007年第10期715-717,共3页 Chinese Journal of Hematology
关键词 未折叠蛋白反应 多发性骨髓瘤 治疗 蛋白酶体系统 蛋白降解 应激状态 蛋白质翻译 细胞器
分类号 R733.3 [医药卫生—肿瘤]
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参考文献18

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  • 2Ahner A, Brodsky JL. Checkpoints in ER-associated degradation: excuse me, which way to the proteasome? Trends Cell Biol, 2004, 14: 474 -478.
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同被引文献10

  • 1战丽彬,钟军华,路小光,隋华,韦巍.滋补脾阴方药含药血清对内质网应激神经元损伤的保护作用及机制研究[J].中西医结合学报,2007,5(4):445-450. 被引量：23
  • 2Hou J,Xiong H,Gao W,et al.2-Methoxyestradiol at low dose induces differentiation of myeloma cells.Leuk Res,2005,29:1059-1067.
  • 3Zhou X,Jiang H,Hou J.Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol.Leuk Res,2007,31:1259-1265.
  • 4Gass JN,Jiang HY,Wek RC,et al.The unfolded protein response of B-lymphocytes:PERK-independent development of antibody-secreting cells.Mol Immunol,2008,45:1035-1043.
  • 5Lee AS.The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.Methods,2005,35:373-381.
  • 6Todd DJ,McHeyzer-Williams LJ,Kowal C,et al.XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.J Exp Med,2009,206:2151-2159.
  • 7Carrasco DR,Sukhdeo K,Protopopova M,et al.The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.Cancer Cell,2007,11:349-360.
  • 8Yoshida H,UemuraA,Mori K.pXBP1(U),anegative regulator of the unfolded protein response activator pXBP1(S),targets ATF6 but not ATF4 in proteasome-mediated degradation.Cell Struct Funct,2009,34:1-10.
  • 9Yoshida H.Unconventional splicing of XBP-1 mRNA in the unfolded protein response.Antioxid Redox Signal,2007,9:2323-2333.
  • 10温琥玲,谢建平.多发性骨髓瘤及其骨痛的治疗[J].川北医学院学报,2009,24(2):182-186. 被引量：9

引证文献2

中华血液学杂志
2007年 第10期

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