补肾活血调肝治疗多囊卵巢综合征无排卵性不孕证临床研究

Treatment on anovulatory infertility induced by polycystic ovary syndrome through supplementing kidney and promoting blood circulation

目的:探讨中医补肾活血调肝治疗多囊卵巢综合征PCOS无排卵性不孕证临床研究。方法:将60例PCOS无排卵性不孕证者随机分为治疗组、对照组各30例。治疗组予以自拟中药补肾活血调肝汤;对照组以口服氯米芬治疗。观察治疗前及治疗停药后3个月、6个月患者体内相关的激素及临床症状体征的变化。结果:停药后治疗组患者的总有效率优于对照组;停药后3个月两组患者的激素水平、卵巢体积、排卵率、受孕率、月经情况较治疗前明显改善;停药6个月对照组又回到治疗前的水平;而治疗组的激素水平、卵巢体积、排卵率、受孕率、月经情况仍保持较好的状态。结论:中医补肾活血调肝治疗肾虚肝郁型PCOS无排卵性不孕证近远期疗效优于对照组。

Objectives： To investigate the therapeutic effect of Chinese medicines for invigorating kidney and activating blood and regulating liver in treating the patients with anovulatory sterility of PCOS （ polycystic ovary syndrome）. Methods： 60 cases of patients with anovulatory sterility of PCOS were divided into two groups randomly, 30 cases in the treatment group and 30 cases in the control group. Patients in treatment group were given bushentiaogan decoction, and those in control group were given clomifene, The change of the relative hormones and the clinical symptoms and the signs were observed before the treatment and at 3 months and 6 months after stopping the treatment. Result： The total therapeutic effective rate in the treatment group was better than that in the control group after stopping the treatment. The indicators including the level of hormones, the volume of the ovary, the rate of ovulation, the rate of pregnancy and the menstruate state at 3 months after stopping the treatment in the two group were obviously better than those before the treatment, The levels of the indicators at 6 months after stopping the treatment were similar to those before the treatment in the control group, but the indicators in the treatment group kept in a better level. Conclusion： The short- term and long -term therapeutic effect of Chinese medicines for invigorating kidney and activating blood and regulating liver in treating the patients of kidney deficiency and liver stagnation with anovulatory sterility of PCOS in the treatment group is better than that in the control group.