期刊文献+

老年期抑郁症和轻度阿尔茨海默病的血浆同型半胱氨酸水平及MTHFR基因多态性 被引量:3

原文传递
导出
摘要 本研究拟证实老年期抑郁症和阿尔茨海默病(AD)与血浆同型半胱氨酸(Hcy)水平及其再甲基化过程中的关键酶N^5,N^10-亚甲基四氢叶酸还原酶(MTHFR)的基因多态性的关系。
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2007年第10期767-769,共3页 Chinese Journal of Geriatrics
  • 相关文献

参考文献14

  • 1American Psychiatry Association. Diagnostic and statistical manual of mental disorders, fourth edition (DSM-Ⅳ). Washington DC: APA,1994. 256.
  • 2中华医学会精神科分会.中国精神障碍分类与诊断标准:第3版(CCMD-3)[M].济南:山东科学技术出版社,2001.75—78.
  • 3张颖冬,朱志刚,刘阳.血浆Hcy水平及MTHFR基因多态性与脑梗死的关系[J].中风与神经疾病杂志,2001,18(4):198-200. 被引量:29
  • 4Reutens S, Sachdev P. Homocysteine in neuropsychiatric disorders of the elderly. Int J Geriatr Psychiatry, 2002,17 : 859-864.
  • 5Sechadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med, 2002, 346: 476-483.
  • 6Positiglione A, Milan G, Ruocco A, et al.Plasma folate, vitamin B12, and total homoeysteine and homozygosity for the C677T mutation of the 5, 10-methylrne tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study. Gerontology,2001,47:324-329.
  • 7Reutens S, Sachdev P. Homocysteine in neuropsychiatric disorders of the elderly. Int J Geriatr Psychiatry,2002,17 : 859- 864.
  • 8Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry, 2000,69 : 228-232.
  • 9Tiemeier H, van Tuijl HR, Hofman A, et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry, 2002, 159: 2099-2101.
  • 10Wakutani Y, Kowa H, Kusumi M,et al. A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease. Neurobiol Aging, 2004,25 : 291-294.

二级参考文献16

  • 1沈佐君,吴琳.高效毛细管电泳法快速测定血清中游离氨基酸[J].中华检验医学杂志,1998,22(3):22-25. 被引量:22
  • 2江三多,冯国鄞,吴晓东,林嗣萃,顾牛范,金通观,康伟民,高哲石,任大明,江开达.Alzheimer病与载脂蛋白E ε_4等位基因的关联分析[J].中华精神科杂志,1996,29(1):15-18. 被引量:39
  • 3Nishiyama M,Kato Y,Hashimoto M.Apolipoprotein E,methyle netetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method.J Epidemiol,2000,10 :163~172
  • 4Goyette P,Frosst P,Darid SR.Seven novel mutation in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydro-folate reductase deficiency.Am J Hum Genet,1995,56 :1052~1059
  • 5Kruman II,Kumaravel TS,Lohani A.Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experi-mental models of Alzheimer's disease.J Neurosci,2002,22 :1752~1762
  • 6Regland B,Blennow K,Germgard T.The role of the polymorphic genes apolipo-protein E and methylenetetrahydrofolate reductase in the development of dementia of the Alzheimer type.Dement Geriatr Cogn Disord,1999,10 :245~251
  • 7Regine PM,Streegers.The unmissense maternal hyperhomocysteinemia:a risk factor for neural tube defects? Metabolism,1994,42 :1475-1480
  • 8Pollak RD,Pollak A,Idelson M.The C677T mutation in the methylenetetrahydro-folate reductase (MTHFR) gene and vascular dementia.J Am Geriatr Soc,2000,48 :664-668
  • 9Chapman J,Wang N,Treves TA.ACE,MTHFR,factor V Leiden,and APOE poly-morphisms in patients with vascular and Alzheimer's dementia.Stroke,1998,29 :1401-1404
  • 10Ysoe C,Galinsky D,Robinson D.Analysis of alpha-1 antichymotrypsin,presenilin-1,angiotensin-converting enzyme,and methylenetetrahydrofolate reductase loci as candidates for dementia.Am J Med Genet,1997,74 :207-212

共引文献31

同被引文献10

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部