摘要
磷酸盐初始浓度6.1mmol/L^9.6mmol/L有助于菌体的生长,但抑制氨基糖苷类抗生素JI-20A的合成。在产物合成期磷酸盐浓度控制在1.1mmol/L以下可提高碱性磷酸酯酶活力,降低丙酮酸浓度,促进氨基糖苷类抗生素JI-20A合成。
It was found that the phosphate concentration effected significantly on the cell growth and the production of aminoglycoside antibiotic JI- 20A. Although initial phosphate concentration of 6. 1mmol/L - 9.6 mmol/L was beneficial for the cell growth, the production of aminoglycoside antibiotic JI-20A was inhibited. When the phosphate concentration was controlled below 1.1 mmol/L in the biosynthesis phase of aminoglycoside antibiotic JI-20A, high alkaline phosphatase activity and low pyruvic acid concentration were resulted in, and the production of arninoglycoside antibiotic JI-20A was enhanced.
出处
《微生物学通报》
CAS
CSCD
北大核心
2007年第5期852-855,共4页
Microbiology China
基金
福建省科技三项基金项目(NoK20011)
福建省自然科学基金项目(NoC0210007
B9810007)
