1LaUy FJ, Ratcliff H, Bone AJ. Apoptosis and disease progression in the spontaneously diabetic BB/S rat [J]. Diabetotogia 2001 ; 44 : 320 - 324.
2Kurrer M O, Pakala S V, Hanson H L, et al. T cell apoptosis in T cell - mediated autoimmune diabetes [J]. Proe Natl Acad Sei USA 1997,94:213 - 218.
3Loweth AC, Willims GT, James RFL, et al. Human islets oflangerhans express fas ligand and tmdergo apoptosis in response to interleukin- 1β and Fas ligation[J], diabetes 1998;47(5) :727 - 732.
5Stassi G, Maria DE, Tracco R, et al. Nitric Oxide primes pancreatic βcells for Fas mediated destruction in insulin - dependent diabetes meUitus[J] .J Exp Med 1997;186:1193-1200.
2Roland T. Insulin dependent diabetes mellitus [J].Cell,1996,85: 291-297.
3Oarada S, Wu Y, Olshansky G, et al. Increased non obese diabetic Thl:Th2 (IFN-garnma:lL-4) ratio is CD4+T cell intrinsic and independent of APC genetic background [J]. J Immunol,2002,169 ( 11 ): 6580-6587.
4Xu A J, Zhu W, Tian F, et al. Recombinant adenoviral expression of IL-10 protects beta cell from impairment induced by pro-inflammatory cytokine [J].Mol Cell Biochem.2010,344 (1-2): 163-171.
5Mi QS, Dalam L, Peter Z, et al.Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CDldrestricted invariant natural killer T-cells [J]. Diabetes, 2004,53(5):1303-1310.
6Gregg RK, Bell JJ, Lee HH, et al. IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance[J].J Immunol, 2005,174(2):662-670.
7Falcone M,Yeung B,Tucker L, et al.IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic Islets [J]. Clin Immunol, 2001,98(2): 190-199.
8Dudek NL, Thomas HE, Mariana L, et al. Cytotoxic T-cells from ]?-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways[J]. Diabetes,2006,55 (9):2412-2418.
9Allison J, Thomas HE, Catterall T, et al. Transgenic expression of dominant-negative fas-associated death domain protein in B cells protects against fas ligand-induced apoptosis and reduces spontaneous diabetes in Nonbese diabetes mice [J].J Immunol. 2005,175 (1): 293-301.
10Su X, Hu Q, Kristan JM, et al. Significant role for Fas in the pathogenesis of autoimmune diabetes [J]. J Immunol, 2000, 164(5): 2523-2532.
