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香港海藻网胰藻中抗病毒活性多糖的分离与纯化 被引量:2

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摘要 采用生物活性追踪的方法从香港海藻网胰藻(Hydroclathrus clathratus)中分离具有抗病毒活性的多糖,其中H3-a1和H3-b1纯度较高,它们表现出很强的抗单纯疱疹病毒Ⅱ型活性,且细胞毒性很小.通过高压液相色谱(HPLC)、紫外扫描、气相色谱、红外分光光谱和元素分析等方法对这2种多糖进行鉴定,发现它们是2种由不同单糖成分组成的高分子量硫酸多糖,分别含有一定量的蛋白质和糖醛酸.同时,从网胰藻水提物中分离到的多糖显示较低的抗凝血活性.在分离纯化过程中,多糖的抗病毒活性随着硫酸基含量的变化而变化.
出处 《中国科学(C辑)》 CSCD 北大核心 2007年第5期508-515,共8页 Science in China(Series C)
基金 香港特别行政区研究资助局(批准号:CUHK4367/01M) 香港中文大学科研经费资助项目
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