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哺乳动物cd59基因的进化 被引量：3

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摘要 采用PCR以及BLAST方法从5种哺乳动物中获得了cd59基因的编码区序列,结合GenBank中已有的序列,计算cd59基因在哺乳动物中的核苷酸替换速率.对非同义替换速率和同义替换速率进行比较的结果显示,cd59在哺乳动物中总体上受到负选择作用;用PAML软件"位点-特异"模型检测到4个受到正选择作用的位点,4个位点分布于分子表面,其中2个位于功能重要的区域;此外,用"支-位点-特异"模型在小鼠通过基因复制后形成的cd59a和cd59b上检测正选择引起的加速进化,并检测到该支系特异的正选择位点1个.
作者 龚远英 彭旻晟 周伟平 张亚平
机构地区 中国科学院昆明动物研究所遗传资源与进化国家重点实验室
出处 《中国科学（C辑）》 CSCD 北大核心 2007年第5期544-550,共7页 Science in China(Series C)
基金 国家自然科学基金(批准号:30621092 30430110) 国家重点基础研究发展计划(批准号:2007CB411600) 云南省科技厅资助项目.
关键词 CD59 进化 正选择
分类号 Q953 [生物学—动物学]
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参考文献39

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同被引文献61

  • 1张蕾蕾,吴李君,韩伟,陈少鹏,鲍凌志,赵烨,余增亮.应用hprt和CD59基因研究辐射旁效应的产生及机理[J].中国科学院研究生院学报,2006,23(6):752-758. 被引量：4
  • 2肖毅,杨粉莲.两种提取红细胞膜蛋白方法的比较[J].细胞与分子免疫学杂志,1997,13(2):44-45. 被引量：4
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  • 7Aebi M,Fah J,Hurt N.cDNA structures and regulation of two interferon-induced human Mx proteins[J].J Mol Cell Biol,1989,9:5 062-5 072.
  • 8Jin H K,Takada A,Kon Y,et al.Identification of the murine Mx2 gene:interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus[J].Journal of Virology,1999,73 (6):4 925-4 930.
  • 9Ooi E L,Hirono I,Aoki T,et al.Functional characterisation of the Japanese flounder,Paralichthys olivaceus,Mx promoter[J].Fish & Shellfish Immunology,2006,21 (1):293-304.
  • 10Ko J H,Jin H K,Asano A,et al.Polymorphisms and the differential antiviral activity of the chicken Mx gene[J].Genome Res,2002,12:595-601.

引证文献3

中国科学（C辑）
2007年 第5期

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