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性早熟女童血浆胃促生长素水平的研究 被引量：2

Study on plasma ghrelin level in girls with precocious puberty
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摘要 以放射免疫法对性早熟女童(除外周围性性早熟)进行血浆胃促生长素测定。结果显示性早熟女童血浆胃促生长素水平与Tanner期、骨龄、GnRH激发后15、30和60 min的LH、子宫、卵巢容积呈负相关;中枢性性早熟组血浆胃促生长素水平明显低于部分性性早熟组和对照组,差异有统计学意义(均P<0.05)。 [ Summary] Plasma ghrelin level was measured by RIA in 49 girls with idiopathic central precocious puberty （ICPP） and 35 girls with simple premature thelarche （PT）. The results showed that the plasma ghrelin level was negatively correlated with Tanner stage, bone age, LH at 15, 30 and 60 rain after GnRH activation, uterus and ovary volumes. The plasma ghrelin level in the ICPP group was remarkably lower than that in the PT and control groups （ both P 〈 0.05 ）.
作者 朱红 蒋优君 梁黎 邹朝春 陈黎勤
机构地区 浙江大学医学院附属儿童医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第5期408-409,共2页 Chinese Journal of Endocrinology and Metabolism
基金 浙江省科技厅科研基金(2004C33035) 浙江省卫生厅基金(2006A075)
关键词 青春期 早熟 胃促生长素 女童 Puberty, precocious Ghrelin Girls
分类号 R725.8 [医药卫生—儿科]
  • 相关文献

参考文献9

  • 1Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999,402:656-660.
  • 2Chanoine JP. Ghrelin in growth and development. Horm Res, 2005,63: 129-138.
  • 3Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function. Growth Honn IGF Res, 2005,15:83-88.
  • 4邵莉,李荣英,张一波,赵双霞,乔洁,朱鋐达,陈名道.不同饥饿时段对常规及高脂饮食大鼠胃壁组织胃促生长素(ghrelin)表达的影响[J].中华内分泌代谢杂志,2005,21(3):265-268. 被引量：7
  • 5中华医学会儿科学分会内分泌遗传代谢学组.对中枢性(真性)性早熟诊断和治疗的建议[J].中华儿科杂志,2003,41(4):272-273. 被引量：128
  • 6Veldhuis JD, Bowers CY. Human GH pulsatility: an ensemble property regulated by age and gender. J Endocrinol Invest, 2003,26:799-813.
  • 7沈红,梁黎,邹朝春,张嬿.不同生长激素激发试验时矮小男童血浆胃促生长素水平[J].中华内分泌代谢杂志,2007,23(1):55-56. 被引量：2
  • 8Fumta M, Funabashi T, Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun, 2001, 288:780-785.
  • 9Mastsubara M, Sakatal I, Wada R, et al. Estrogen modulates ghrelin expression in the female rat stomach. Peptides, 2004,25:259-297.

二级参考文献16

  • 1Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 1999,402:656-660.
  • 2Bertile F, Oudart H, Criscuolo F, et al. Hypothalamic gene expression in long-term fasted rats: relationship with body fat. Biochem Biophys Res Commun, 2003,303:1106-1113.
  • 3Lu S, Guan JL, Wang QP, et al. Immunocytochemical observation of Ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett, 2002,321:157-160.
  • 4Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med, 2002,346:1623-1630.
  • 5Maier C, Schaller G, Buranyi B, et al. The cholinergic system controls ghrelin release and ghrelin-induced growth hormone release in humans. J Clin Endocrinol Metab, 2004,89:4729-4733.
  • 6Inui A, Asakawa A, Bowers CY, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J, 2004,18:439-456.
  • 7Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 2000,141:4325-4328.
  • 8Beck B, Richy S, Stricker-Krongrad A. Ghrelin and body weight regulation in the obese Zucker rat in relation to feeding state and dark/light cycle. Exp Biol Med (Maywood), 2003,228:1124-1131.
  • 9Kamegai J, Tamura H, Shimizu T, et al. Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach. Regul Pept, 2004,119:77-81.
  • 10Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem, 2004,50:1511-1525.

共引文献134

同被引文献40

  • 1Ahmed ML, Ong KK, Dunger DB. Childhood obesity and the timing of puberty. Trends Endocrinol Metab, 2009,20 ( 5 ) : 237-242.
  • 2Roa J, Garcla-Galiano D, Castellano JM. Metabolic control of puber- ty onset :New players, new mechanisms. Mol Cell Endocrinol,2010, 324(1-2) :87-94.
  • 3Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone- releasing acylated peptide from stomach. Nature, 1999,402 (6762) : 656-660.
  • 4Lorenzi T, Meli R, Marzioni D, et al. Ghrelin: a metabolic signal affecting the reproductive system. Cytokine Growth Factor Rev, 2009,20 ( 2 ) : 137-152.
  • 5Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obesta- tin: Three pieces of the same puzzle. Peptides, 2008,29 ( 7 ) : 1255- 1270.
  • 6Guan JL, Okuda H, Takenoya F, et al. Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arca- ate nucleus. Regul Pept,2008,145 (1-3) :128-132.
  • 7Toshinai K, Date Y, Murakami N, et al. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology, 2003,144 ( 4 ) : 1506-1512.
  • 8Cowley MA, Smith RG, DianoS, et al. The distribution and mech nism of action of ghrelin in the CNS demonstrates a novel hypoth larnic circuit regulating energy homeostasis. Neuron, 2003,37 (4)l 649 -661. /.
  • 9Mitsuyo S, Yoshihiro O, Ken E, et al. Ghrelin, an endogenous growth hormone secretagogue,is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y! Y1 receptor pathway. Diabetes,2001,50(2) :227-232.
  • 10Guan JL, Okuda H, Takenoya F, et al. Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcu- ate nucleus. Regul Pept,2008,145 ( 1-3 ) : 128-132.

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中华内分泌代谢杂志
2007年 第5期

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