摘要
介绍了近20年来利用消旋体拆分法、非对映选择性醇醛缩合法、Paal-Knorr反应、环加成法、双羰基不对称还原法等,完成阿托伐他汀全合成的研究进展。分析了各条路线的关键步骤,讨论了各方法的特点。参考文献27篇。
Recent progress in total synthesis of Atrovastatin were reviewed. The key reaction steps and characteristics of each important synthetic route were analyzed and discussed. 27 References were cited.
出处
《合成化学》
CAS
CSCD
2007年第5期519-527,594,共10页
Chinese Journal of Synthetic Chemistry
基金
浙江华海药业股份有限公司资助项目
关键词
阿托伐他汀
全合成
综述
Atovastatin
total synthesis
review