3-羟基十四酸的合成

Synthesis of 3-Hydroxytetradecanoic Acid

以环氧氯丙烷为起始原料,经5步反应合成了3-羟基十四酸,总收率52.48%。以氯癸烷替代溴癸烷做格氏反应,有效地降低了偶联副产物的生成;从中间产物1-氯-2-羟基十三烷直接上氰基,避免了环化后上氰基时生成氢氰酸的危险。

3-Hydroxytetradecanoic acid was synthesized by a five-step reaction from epichlorohydrin in overall yield of 52.48%. The decyl chloride was used instead of 1-bromodecane to produce Grignard reagent to reduce production of the byproduct eieosane; intermidiate 1-ehloro-2-hydroxytridecane was used directly to react with sodium cyanide, which could avoid generating virulent hydrocyanic acid.