摘要
以2,3-二氯苯胺为原料,经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%,91%和90%;总收率68%。阿立哌唑的结构经1H NMR,IR和元素分析表征。
Aripiprazole in overall yield of 68% was synthesized from 2,3-diehloroaniline by a three-step nueleophilie substitution reaction in yield of 83%, 91% and 90%, respectively. The structure was characterized by ^1H NMR, IR and elemental analysis.
出处
《合成化学》
CAS
CSCD
2007年第5期653-655,共3页
Chinese Journal of Synthetic Chemistry
关键词
阿立哌唑
亲核取代反应
药物
合成
Aripiprazole
nucleophilic substitution reaction
drug
synthesis
