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乳脂肪球膜主要膜蛋白功能的研究进展 被引量：5

The Advance of Fuction on Milk Fat Globule Membrane Proteins
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摘要 嗜乳脂蛋白(butyrophilin,Btn)、黄嘌呤氧化还原酶(XOR)和乳脂肪球表面生长因子8(MFG-E8)是乳脂肪球膜的3种主要膜蛋白。最近的研究发现,Btn和XOR在乳脂肪的分泌阶段是必不可少的。而MFG-E8在乳腺泌乳晚期及衰退期,对清除凋亡的乳腺上皮细胞起着重要作用。 Btn, XOR and MFG-E8 are three membrane proteins of milk fat globule membrane（MFGM）. Recent findings in- dicate that both Btn and XOR are indispensable for milk fat secretion. MFG-E8 plays a critical role in eliminating apoptotic mammary epithelial cells during involution.
作者 都军霞 韩立强 乔新安 杨国宇
机构地区 河南农业大学牧医工程学院
出处 《中国畜牧兽医》 CAS 2007年第10期63-65,共3页 China Animal Husbandry & Veterinary Medicine
关键词 乳脂肪球膜 嗜乳脂蛋白 黄嘌呤氧化还原酶 乳脂肪球表面生长因子8 milk fat globule membrane butyrophilin XOR MFG-E8
分类号 Q516 [生物学—生物化学]
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参考文献10

  • 1Abrahams V M, Kim Y M, Straszewski, et al, Macrophages and apoptotic cell clearance during pregnancy[J]. Reprod Immunol, 2004,51:275-282.
  • 2Aoki N, Kuroda H, Urabe M, et al. Production and characterization of monoclonal antibodies directed against bovine milk fat globule membrane(MFGM) [J]. Biochim Biophys Acta, 1994, 1199:87-95.
  • 3Aoki N, Matsuda T, Sakiyama T, et al. Species-specific beta-N- acetylgalactosa-minylation of serum IgG proteins [J]. Bioehim Biophys Acta, 1997,1334:207-213.
  • 4Bruder G, Heid H, Jarasch E D, et al. Characteristics of membrane bound and soluble forms of xanthine oxidase from milk and endothelial cells of capillaries[J]. Biochim Biophys Acta, 1982, 701:357-369.
  • 5Franke W W, Heid H W, Grund C, et al. Antibodies to the major insolution milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cell[J]. Cell Biol, 1981,89: 485-494.
  • 6Hanayama R, Tanaka M, Miwa, et al. Identification of a factor that links apoptotic cells to phagocytes[J]. Nature, 2002,417: 182-187.
  • 7Hennighausen L, Robinson G W. Signaling pathways in mammary gland development[J]. Dev Cell, 2001(1):467-475.
  • 8Nakatani H, Aoki N, Nakagawa Y, et al. Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands as demonstrated by the amalyses of its mRNA, protein and phosphatidylserine-binding activity[J]. Biochem, 2006, 395:21-30.
  • 9Ogg S L, Weldon A K, Dobbie L, et al. Expression of Btn (Btnlal) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets[J]. Natl Acad Sci USA, 2004,101: 10084-10089.
  • 10Vorbach C, Scriven A, Capecchi M R. The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland [J]. Genes Dev, 2002,16:3223-3235.

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中国畜牧兽医
2007年 第10期

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