101例儿童急性髓细胞性白血病免疫表型与预后相关分析

Prognostic relevance of immunophenotyping in 101 children with acute myeloid leukemia

目的探讨免疫表型对儿童急性髓细胞性白血病的预后价值。方法采用流式细胞术检测101例儿童急性髓细胞性白血病(AML)患儿相关免疫表型,分析免疫表型对完全缓解(CR)及无疾病生存期(DFS)的影响。结果CD34阴性组及CD34、HLA-DR同时阴性组一疗程CR率均明显高于非阴性组,差异有统计学意义(P=0.008,0.000);DFS的CD34阴性组,HLA-DR阴性组以及CD34和HLA-DR同时阴性组均明显高于非阴性组,差异有统计学意义(P=0.004,0.006,0.040),而CD14,CD15,CD7,CD19差异对CR和DFS均无统计学意义。结论免疫表型对评估AML患儿的预后有一定意义。

Objective To assess the acute myeloid leukemia （AML）. Methods prognostic value of the immunophenotyping in childhood Immunophenotyping was performed in 101 patients by flow cytometry analysis. Results CD34 positive patients had a significantly lower CR rate （P = 0. 008 ）, CD34 and HLA-DR both negative had a higher CR rate （ P = 0. 000） ; Duration of disease free survival （DFS） was significantly shorter for patients with CD34 positive （P = 0. 004） or patients with HLA-DR positive （P =0. 006）. CD34 and HLA-DR both negative had a longer duration of DFS （P =0. 04）. But CD14, CD15, CD7, CD19 were not associated with treatment outcome. Conclusion Immunophenotyping is not only helpful for diagnosis, but can used for a prognostic score.