模拟移动床色谱分离制备手性农药甲霜灵的研究

Study on separation and preparation of chiral farm insecticide metalaxyl by simulated moving bed chromatography

利用自行组建的模拟移动床色谱(SMBC),在正相条件下,在自制的涂敷型纤维素-三(3,5-二甲基苯基氨基甲酸酯)手性固定相上成功制备出甲霜灵对映体,所制备的对映体纯度达到99%以上,与高效液相色谱法制备相比较,模拟移动床技术制备甲霜灵对映体的效率以及流动相的利用率均明显高于高效液相色谱法。

Metalaxyl isomers with purity of higher than 99% were firstly prepared successfully on self-made chiral stationary phase of coated cellulose tris（3,5-dimethylphenylcarbamate） under normal phase condition with self-equipped stimulated moving-bed chromatography （SMBC）. Compared to HPLC, the efficiency and the utility of mobile phase with SMBC technology were apparently better.