长春瑞滨加顺铂治疗转移性乳腺癌40例疗效分析

Analysis of 40 Cases of the Treatment of Metastatic Breast with Navelbine(NVB) Plus Cisplatin

目的研究长春瑞滨（NVB）和顺铂（DDP）联合化疗方案在转移性乳腺癌治疗中的疗效和毒副作用。方法采用NVB 25mg/m^2第18、d,DDP 25mg/m^2第1、2、3 d,28 d为1周期,共用2～4周期,随访6～36个月。结果40例患者62处转移灶中,完全缓解（PR）27.2%（17/62）,部分缓解（PR）27.42%（17/62）,稳定（SD）32.26%（20/62）,SD≥6个月者19.35%（12/62）,进展（PD）14.52%（9/62）,客观有效率（ORR为CR＋PR）54.84%,临床获益率（CR＋PR＋SD≥6个月）74.19%（46/62）,中位疾病进展时间TTP为7个月,对锁骨上淋巴结转移的有效率最高达83.33%,毒副反应主要为白细胞减少和脱发。Ⅲ～Ⅵ度白细胞减少发生率为67.5%。结论长春瑞滨加顺铂在转移性乳腺癌治疗中疗效显著,不良反应可耐受。

Objective To investigate the therapeutie effect and toxicity of combination chemotherapy with navelbine （NVB） and cisplatin（DDP） in treating metastatic breast cancer. Methods 40 patients with metastatic breast cancer were treated with combination chemotherapy of vinorelbine 25 ing/m^2 d1,8, DDP 25 mg/m^2 d1,2,3,28 days for a cycle, a total of 2 - 4 cycles, made tracks for 6 - 36 months. Results Among 40 patients with 62 metastatis, CR was 27.42 % （17/62）, PR27.42 % （17/62）, SD32.26 % （20/62）, SD I〉 6 months, 19.35 % （ 12/62）, PD14.52% （9/62）, ORP（CR ＋ PR）54.84%, （CR ＋ PR ＋ SD ≥ 6 months） 74.19% （46/62）, and TIP was 7 months. The value of the efiqciency to the lymph metastssis above the clacicle was 83.33% .The toxicity was leucopenia and losing hair.67.5% of cases was in Grade Ⅲ and Grade Ⅳ leucopenia. Conclusion The combination chemotherapy with navelbine（NVB） and cisplatin （DDP） in treating metastatic breast cancer is effective and has acceptable tolerance.