糖耐量低减患者动态血压与尿白蛋白排泄率的关系

Relationship between 24-h ambulatory blood pressue and urinary albumin excretion in patients with impaired glucose tolerance

目的 探讨糖耐量低减(IGT)患者尿白蛋白排泄率(UAE)与不同血压指标的关系。方法 对44例IGT患者均进行动态血压(ABPM)监测,心血管自主神经功能测试,UAE测定。结果 与UAE正常组比较,UAE增高组ABPM多项指标增高,夜间血压降低幅度减少,24小时血压曲线平坦。UAE与夜间舒张压(DBP)、收缩压(SBP)负荷、DBP负荷、24hDBP以及24hSBP呈显著正相关,与昼夜血压差值呈显著负相关。结论 UAE增高的IGT患者已经开始出现血压的异常改变。

Objective To investigate the relationship between the UAE and the change of 24-h ambulatory blood pressure (ABPM) in impaired glucose tolerance (IGT) patients. Methods ABPM, heart autonomic nerve function and urinary albumin excretion (UAE) examination were performed in 44 IGT patients. Results Many indexes of ABPM were significantly higher in the IGT with elevated UAE than that in IGT with normal UAE. In high UAE group, the reduction of nocturnal blood pressure was decreased and the profile of 24h blood pressure was smoother compared with normal UAE group. A significant positive correlation was found between the UAE and nighttime DBP, blood pressure load of SBP and DBP, 24hDBP and 24hSBP. There was a negative correlation between the UAE and the decreased rate in nighttime blood pressure (,SBP, -,DBP and ,-MBP). Conclusion IGT patients with elevated UAE have had early changes of blood pressure in ABPM.