期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

双相情感障碍分子遗传学研究进展

下载PDF
导出
摘要 在情感障碍病因中，遗传因素的影响远大于环境因素，尤其是双相情感障碍较单相情感障碍更具有明显的遗传倾向？自从1987年Egeland等报告双相情感障碍易感基因可能是在11号染色体的短臂（11P15．5）上，双相情感障碍分子遗传学研究已成为当今医学分子生物学的研究热点。目前双相情感障碍的分子遗传学研究主要集中于神经递质方面的基因。为此，本文对双相情感障碍与五羟色胺系统和多巴胺系统等基因关联综述如下：
作者 周云飞 刘铁榜
机构地区 深圳市康宁医院
出处 《中国行为医学科学》 CSCD 2007年第10期954-956,共3页 Chinese Journal of Behavioral Medical Science
关键词 双相情感障碍 分子遗传学 医学分子生物学 多巴胺系统 11号染色体 易感基因 环境因素 遗传因素
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献20

  • 1江三多．精神障碍与遗传．见：张亚林主编．精神病学．北京：人民教育出版社,2005．63-75．
  • 2Meira-Lima I, Michelon L, Cordeiro Q,et al. Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affectivc disorder. J Mol Neurosci ,2005,27:219-224.
  • 3谢光荣,赵敏,张向晖,苏林雁.5-HT_(2A)受体基因-1438G/A多态性与情感障碍的关联研究[J].中国行为医学科学,2006,15(1):4-6. 被引量：13
  • 4Meyer J, Saam W, Mossner R, et al. Evolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in females. J Neural Transm, 2002,109 : 939 -946.
  • 5Lin YM, Yang HC, Lai TJ, et al. Receptor mediated effect of serotonergic transmission in patients with bipolar affective disorder J. Med Genet, 2003,40:781-786.
  • 6Keikhaee MR, Fadai F, Sargolzaee MR, et al. Association analysis of the dopamine transporter (DAT1)-67A/T polymorphism in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet,2005,135:47-49.
  • 7Greenwood TA, Schork NJ, Eskin E, et al. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent sampies. Mol Psychiatry,2006 , 11 : 125-133.
  • 8Severino G, Congiu D, Serreli C, et al. A48G polymorphism in the D1 receptor genes associated with bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet ,2005, 134 : 37-38.
  • 9Dmitrzak-Weglarz M, Rybakowski JK, Slopien A, et al. Dopamine receptor D1 gene -48A/G polymorphism is associated with bipolar illness but not with schizophrenia in a Polish population. Neuropsychobiology, 2006,53:46-50.
  • 10Anna Leszczynska-Rodziewicz, Joanna Hauser, Monika Dmitrzak-Weglarz, et al. Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population. Med Sci Monit,2005, 11: 289-295.

二级参考文献10

  • 1Yong Yong SHI,Lin HE.SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J].Cell Research,2005,15(2):97-98. 被引量：384
  • 2Schwartz PJ, Turner EH, Garcia-Borreguero D, et al. Serotonin hypothesis of winter depression : behavioral and neuroendocrine effects of the 5HT(1 A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. Psychiatry Res, 1999,86:9-28.
  • 3Murphy DL, Andrews AM, Wichems CH, et al. Brain serotonin neurotransmission : an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry, 1998,59 Suppl 15:4-12.
  • 4Gershon ES, Hamovit J, Guroff JJ, et al. A family study of schizoaffective, bipolar Ⅰ, bipolar Ⅱ, unipolar, and normal control probands. Arch Gen Psychiatry, 1982,39 : 1157-1167.
  • 5Tsuang MT, Winokur G, Crowe RR. Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br J Psychiatry,1980,137:497-504.
  • 6Bertelsen A, Harvald B, Hauge M. A Danish twin study of manic-depressive disorders. British Journal of Psychiatry, 1997,130:330-351.
  • 7Mendlewicz J, Rainer JD. Adoption study supporting genetic transmission in manicdepressive illness. Nature,1997,268:327-329.
  • 8Wender PH, Kety SS, Rosenthal D, et al. Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Arch Gen Psychiatry, 1986,43:923-929.
  • 9Serretti A, Lattuada E, Catalano M, et al. Serotonin transporter gene not associated with psychotic symptomatology of mood disorders. Psychiatry Res, 1999,86:59-65.
  • 10吴兴曲,杨来启,王晓峰,李拴德,马文涛,杨喜民,刘光雄.睡眠剥夺后大鼠大脑5-HT1A和5-HT2A受体的表达[J].中国行为医学科学,2002,11(4):364-365. 被引量：7

共引文献19

中国行为医学科学
2007年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部