不同加药环境对输液微粒影响的探讨

Discussion about the Effects of Clinical Different Adding the medicine Environment on Transfusion Particles

目的探讨不同环境加药对输液微粒数的影响。方法分别测定A（100级净化台内）、B（10万级洁净房间）、C（治疗室清洁消毒后10min）、D（治疗室清洁消毒后240min）环境空气的微粒、细菌数，并在相应环境下进行输液加药，然后分别检测加药后输液的不溶性微粒数。结果A为净化环境；B较一类洁净环境；C接近二类环境标准；D细菌数超出三类环境3．13倍；A、B加药后输液的微粒数符合药典要求，C加药输液的微粒数接近药典要求，D加药后输液的微粒数超出药典要求数倍（10pm以上超4．37倍，25μm以上超8．31倍）。结论A环境是最理想的加药环境，B环境是良好的加药环境；在没有净化条件的情况下，C环境可作为加药环境，D环境不可作为加药环境。

Objective To study the influence of insoluble particle in intravenous injection liquids adding the medicine on different environment. Methods To determine the particle and bacteria on A environment （100 class clean areas in hospital pharmacy）, B environment （ 100 000 class clean room）, C environment （ after the treatment room clean to , disinfect 10 minutes）, and the D environment （ after the treatment room clean to disinfect 240 minutes） and to determine insoluble particle in intravenous injection liquids adding the medicine on A, B, C and D environment respectively. Results A environment are clean surroundings; B environment are cleaner than the first kind of environment; C environment are close to the second kind of environment criterion： Denvironment is 3. 13 times over the third environment on bacteria; A environment and Benvironment accord with the request of pharmacopoeia on transfusion particles after adding the medicine; C environment is close to the request of pharmacopoeia on transfusion particles after adding the medicine; D environment is 4. 37 times over the request of pharmacopoeia on transfusion particles after adding the medicine. Conclusion The insoluble particle in intravenous injection adding the medicine on A, B, C environment had accorded with the demands of pharmacopoeia; D environment had not ; The improvement adding the medicine environment should be taken into account urgent.