单克隆抗体SMU_2、SMU_7在白血病中的表达及临床诊断价值的初步探讨

THE EXPRESSION OF MONOCLONAL ANTIBODIES SMU 2,SMU 7 ON LEUKEMIC CELLS AND THEIR CLINICAL DIAGNOSTIC VALUE

将自行制备的单克隆抗体（单抗）ＳＭＵ２、ＳＭＵ７通过１３６例淋巴细胞白血病和１３２例非淋巴细胞白血病进行免疫表型分析，表明它们主要在ＡＭＬ、ＣＭＬ、Ｔ－ＡＬＬⅢ和Ｔ－ＣＬＬ中表达，在其它白血病中基本不表达，并且在非淋巴细胞白血病中的表达阳性率高于ＣＤ３３等粒单单抗。初步表明，ＳＭＵ２、ＳＭＵ７属非系限性单抗，联合应用淋巴系、粒单系单抗，有助于提高白血病类型、分化阶段判定的准确率。

The expression of monoclonal antibodies SMU 2 and SMU 7 was studied on 136 cases of lymphocytic leukemia and 132 cases of non lymphocytic leukemia with immunophenotyping analysis.SMU 2 and SMU 7 mainly reacted with surface antigens on acute and chronic myeloid leukemia and mature T lymphocytic leukemia T ALL Ⅲ and T CLL,and failed to reacted with B ALL and B CLL.The reactive distribution of SMU 2 and SMU 7 compared well with CD 33 and some other monoclonal antibodies against granulocytemonocyte cells.Further,SMU 2 and SMU 7 showed higher positive rate on AML than that of CD 33 and other MCAbs of myeloid lineage.SMU 2 and SMU 7 are useful reagents for the diagnosis and classification on leukemias especially the un classified leukemias.