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常见免疫抑制剂与高脂血症的关系 被引量：8

Relationship between common immunosuppressants and hyperlipidemia
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摘要 一些免疫抑制剂影响了脂质的合成与分解,是导致器官移植术后高脂血症的主要因素。现就目前临床常用的免疫抑制剂与高脂血症关系的最新研究进展作一综述。 Some immunosuppressants influence the synthesis and metabolism of lipids, which is a major factor for hyperlipidemia in organ transplant patients. The recent studies on the relationship between immunosuppressants and hyperlipidemia are reviewed.
作者 牛冬梅 张春妮
机构地区 南京军区南京总医院解放军临床检验医学研究所
出处 《医学研究生学报》 CAS 2007年第10期1068-1071,1075,共5页 Journal of Medical Postgraduates
基金 国家自然科学基金资助项目(批准号:30471649) 江苏省六大人才高峰基金资助项目(批准号:20050203)
关键词 免疫抑制剂 高脂血症 脂质代谢紊乱 器官移植 Immunosppressant Hyperlipidemia Metabolic disturbance of lipid Organ transplant
分类号 R392.7 [医药卫生—免疫学]
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参考文献27

  • 1Law YM,Yim R,Agatisa P,et al.Lipid profiles in pediatric thoracic transplant recipients are determined by their immunosuppressive regimens[J].J Heart Lung Transplant,2006,25 (3):276-282.
  • 2Akbas SH,Yurdakonar E,Yucetin L,et al.Relation of C-2 monitoring with serum lipid profile in stable renal transplant patients[J].Transplant Proc,2006,38(2):460-462.
  • 3Kimak E,Solski J,Baranowicz-Gaszczyk I,et al.A long-term study of dyslipidemia and dyslipoproteinemia in stable post-renal transplant patients[J].Ren Fail,2006,28 (6):483-486.
  • 4Spinelli GA,Felipe CR,Machado PG,et al.Relationship of cyclosporin and sirolimus blood concentrations regarding the incidence and severity of hyperlipidemia after kidney transplantation[J].Braz J Med Res,2006,39(1):19-30.
  • 5Hulzebos CV,Bijleveld CM,Stellaard F,et al.Cyclosporine A-induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation[J].Liver Transpl,2004,10 (7):872-880.
  • 6Artz MA,Boots JM,Ligtenberg G,et al.Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus[J].J Am Soc Nephrol,2003,14(7):1880-1888.
  • 7Cheung CY,Wong KM,Chan HW,et al.Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients[J].Transpl Int,2006,19(8):657-666.
  • 8White M,Ross H,Haddad H,et al.Subclinical inflammation and prothrombotic state in heart transplant recipients:impact of cyclosporin microemulsion vs tacrolimus[J].Transplantation,2006,82(6):763-770.
  • 9Aakhus S,Dahl K,Wideroe TE.Hyperlipidaemia in renal transplantation patients[J].J Int Med,1996,239(5):407-415.
  • 10Badiou S,Garrigue V,Dupuy AM,et al.Small dense low-density lipoprotein in renal transplant recipients:a potential target for prevention of cardiovascular complications?[J] Transplant Proc,2006,38(7):2314-2316.

二级参考文献48

  • 1Wang M,Briggs MR.HDL:the metabolism,function and therapeutic importance[J].Chem Rev,2004,104 (1):119-138.
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  • 8Kashyap ML,Tavintharan S,Kamanna VS.Optimal therapy of low levels of high density lipoprotein-cholesterol[J].Am J Cardiovasc Drugs,2003,3 (1):53-65.
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  • 10McKenney JM.Efficacy and safety of rosuvastatin in treatment of dyslipidemia[J].Am J Health Syst Pharm,2005,62 (10):1033-1047.

共引文献30

同被引文献138

引证文献8

二级引证文献34

医学研究生学报
2007年 第10期

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